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Friday, April 17, 2020 | History

6 edition of Aging, glucose intolerance, and non-insulin-dependent diabetes mellitus (Current concepts) found in the catalog.

Aging, glucose intolerance, and non-insulin-dependent diabetes mellitus (Current concepts)

Gerald M. Reaven

Aging, glucose intolerance, and non-insulin-dependent diabetes mellitus (Current concepts)

  • 104 Want to read
  • 22 Currently reading

Published by The Upjohn Company .
Written in English

    Subjects:
  • Age factors,
  • Aging,
  • Diabetes Mellitus, Non-Insulin-Dependent,
  • Non-insulin-dependent diabetes

  • The Physical Object
    FormatUnknown Binding
    Number of Pages27
    ID Numbers
    Open LibraryOL11306778M
    ISBN 100895010208
    ISBN 109780895010209
    OCLC/WorldCa14581083


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Aging, glucose intolerance, and non-insulin-dependent diabetes mellitus (Current concepts) by Gerald M. Reaven Download PDF EPUB FB2

Non Insulin Dependent Diabetes Mellitus. Type 2 diabetes mellitus (DM) is a chronic disease caused by a defect in the secretion of pancreatic insulin and/or an insensitivity of target tissues to its action leading to hyperglycemia,4 contributing to morbidity and mortality.

Type 2 Diabetes Mellitus. Type 2 diabetes mellitus is the most common form of diabetes mellitus and accounts for over 90% of all cases. It was formerly referred to as non-insulin-dependent diabetes mellitus.

Type 2 diabetes mellitus is adult onset, is characterized by insulin resistance, and may also be accompanied by beta cell dysfunction. Glucose intolerance is term for metabolic conditions which result in high blood glucose levels. Pre-diabetes, type 2 diabetes, impaired fasting glucose and impaired glucose tolerance are all conditions which fall under the term glucose intolerant.

Glucose intolerance is defined by. C-peptide measurement in the differentiation of type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus.

Diabetolgia ; – 26 Knight, PV, Kesson, by: 1. Cardiovascular disease risk factors prior to the diagnosis of impaired glucose tolerance and non-insulin dependent diabetes mellitus in a community of older adults. Am J Epidemiol. ; Crossref Medline Google ScholarCited by: Diabetes mellitus (DM) is a metabolic disease affecting the regulation of insulin and glucose causing a disruption in the normal control of counterregulatory hormones and macronutrients, resulting.

Diabetes mellitus is taken from the Greek word Diabetes, meaning siphon - to pass through and the Latin word mellitus meaning sweet. A review of the history shows that the term "diabetes" was first used by Apollonius of Memphis around to BC. Ancient Greek, Indian, Egyptian civilizations discovered the sweet nature of urine in this condition, and hence the propagation of the word.

Represents 90% of all Diabetes Mellitus; Typically occurs over age 40 years in obese patients; Type II Diabetes Mellitus Prevalence is rapidly increasing in the United States.

Prevalence: 22 Million in (was Million in ); More than 8 Million are estimated to be undiagnosed (27%). Chiasson JL. Acarbose for the prevention of diabetes, hypertension, and cardiovascular disease in subjects with impaired glucose tolerance: the Study to Prevent Non-Insulin-Dependent Diabetes Mellitus (STOP-NIDDM) Trial.

Endocr Pract. Jan-Feb. 12 Suppl   INTRODUCTION. Diabetes mellitus (DM) is recognized clinically as a complication of alcoholism, and both alcoholism and DM affect a large population worldwide [].Chronic, heavy alcohol consumption, an independent risk factor for type 2 diabetes mellitus (T2DM) [], disrupts the glucose homeostasis and is associated with development of insulin resistance [].Cited by: 2 diabetes mellitus is the most common type of diabetes and accounts for 90 – 95% of overall diabetes cases [5, 6].

The number of adults with DM in the world elevated from million toAuthor: Asmare Yitayeh Gelaw. Type 2 diabetes is a condition in which cells cannot use blood sugar (glucose) efficiently for energy. This happens when the cells become insensitive to insulin and the blood sugar gradually gets too high.; There are two types of diabetes mellitus, type 1 and type type 2, the pancreas still makes insulin, but the cells cannot use it very efficiently.

Gestational diabetes mellitus (GDM) is caused by the development of glucose intolerance during pregnancy (National Institutes of Health ). In the United States the National Institutes of Health (), U.S.

Preventive Services Task Force (), and the American Diabetes Association () are just a few agencies and organizations who have.

Elahi D, Anderson DK, Muller DC, Tobin JD, Brown JC, Andres R. The enteric enhancement of glucose-stimulated insulin release. The role of GIP in aging, obesity and non-insulin-dependent diabetes mellitus. Diabetes ;– PubMed CrossRef Google ScholarCited by: 2.

Summary. Type 2 diabetes (T2DM) is associated with significant morbidity and mortality, which primarily results from vascular damage. Two major defects contribute to the pathogenesis of T2DM: (1) impaired insulin secretion in response to glucose and other stimuli, i.e., β cell failure; and (2) impaired insulin action in the liver and peripheral (muscle and adipose) tissues, i.e., insulin Cited by: 8.

-glucose is the main source of fuel/energy for the body's cells-food we eat is digested and broken down into glucose, the sugar most common in the blood-glucose passes into the bloodstream to all parts of the body-insulin helps the sugar get from the blood into the cells to be used as their source of energy.

Type 2 diabetes mellitus consists of an array of dysfunctions characterized by hyperglycemia and resulting from the combination of resistance to insulin action, inadequate insulin secretion, and excessive or inappropriate glucagon secretion.

See the image below. Simplified scheme for the pathophysiology of type 2 diabetes mellitus. The definition of type 2 diabetes mellitus, previously termed noninsulin-dependent diabetes mellitus, was recently modified by the American Diabetes Association.

Several criteria may be used independently to establish the diagnosis: 1) a g oral glucose tolerance test with a 2-h value of mg/dL or more, 2) a random plasma glucose of mg Cited by: Diabetes Mellitus, Non-Insulin-Dependent () Definition (MEDLINEPLUS) Diabetes means your blood glucose, or blood sugar, levels are too type 2 diabetes, the more common type, your body does not make or use insulin well.

Mastering Diabetes Book Scientific References. The Revolutionary Method to Reverse Insulin Resistance Permanently in Type 1, TypeType 2, Prediabetes, and Gestational Diabetes.

Our extensively-researched method teaches you how to reverse insulin resistance and maximize longevity using almost years of evidence-based research. Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight.

It is also used in the treatment of polycystic ovary syndrome. It is not associated with weight gain. It is taken by mouth. Metformin is generally well tolerated. Common side effects include diarrhea, nausea, and Pregnancy category: AU: C, US: B (No risk in.

Diet, nutrition and the prevention of type 2 diabetes - Volume 7 Issue 1a - NP Steyn, J Mann, PH Bennett, N Temple, P Zimmet, J Tuomilehto, J Lindström, A LouherantaCited by: In women, it is defined as any degree of glucose intolerance with onset or first recognition during pregnancy (The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, ).

If overt diabetes persists after the pregnancy ends, then it is reclassified as type 1, type 2, or another specific type of diabetes.

The paper "Effects of Glucose/Insulin Perturbations on Aging and Chronic Disorders of Aging" is a perfect example of an assignment on medical science. Perhaps the most important change in aging is increased glucose intolerance. The causes are enhanced insulin resistance at the receptor level or disturbances in the post-receptor level.

Impaired glucose regulation (impaired glucose tolerance, or impaired fasting glucose—see table Diagnostic Criteria for Diabetes Mellitus and Impaired Glucose Regulation) is an intermediate, possibly transitional, state between normal glucose metabolism and diabetes mellitus that becomes more common with is a significant risk factor for DM and may be present for many years before.

Summary of diabetes mellitus (T1DM and T2DM) and consequences: Update based on medical and pathology literature citations: TIDM is insulin-dependent and T2DM is non-insulin dependent in most cases early on, but many have to revert to insulin injections daily to maintain glycaemic targets and when pills fail.

1 Aging as a risk factor for disease. Aging is considered the largest risk factor for a variety of chronic and metabolic diseases [].More than any other individual factor, advancing age increases the risk for type 2 diabetes (T2D), neurodegenerative diseases (i.e., Alzheimer’s disease, Parkinson’s disease), cancer, heart disease, and stroke [].

Cited by: Diabetes Mellitus Type 2 - Diabetes type 2 is known as maturity-onset diabetes or non-insulin-dependent diabetes mellitus. It mainly affects people o many of whom are overweight and have a. The prevalence of obesity has increased dramatically over the past decade [] along with several health risks it encompasses, including non-insulin dependent type 2 diabetes, cardiovascular disease, fatty liver, dyslipidemia, and some types of cancer [].The economic costs of caring for patients with obesity and diabetic complications are enormously high [].Cited by: 4.

Early metabolic defects in the offspring of non-insulin dependent diabetes mellitus patients p. "Obese" NIDDM in normal body weight subjects p. The effect of phlorizin and acipimox on insulin resistance in STZ diabetic rats p.

Longitudinal studies of glucose intolerance in spontaneously diabetic NSY mice p. Our results indicate that there is a relationship between non–insulin-dependent diabetes mellitus and inner ear damage and suggest that OHC loss is related to hyperglycemia and a genetic predisposition for glucose intolerance.

(Arch Otolaryngol Head Neck Surg. ;)Cited by:   Diabetes is a prevalent condition. Just recall all the patients you saw today and there’s probably a handful of them who are diabetic. According to the National Center for Chronic Disease Prevention and Health Promotion Division of Diabetes Translation, up to million people in the United States have diabetes.

And bythe number can increase up to million. therapy on carbohydrate metabolism in patients with glucose intolerance and non insulin dependent diabetes mellitus, DiabetesBoule N, Haddad E, Kenny GP, et al ‘Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus, A meta analysis of controlled clinical trials.

JAMA ;   The incidence of non-insulin-dependent (i.e. Type II) diabetes mellitus (NIDDM) is increasing in adult urban populations around the world. The approximately 3 of adults currently affected by NIDDM will become an estimated 5 by (World Health Organization, ), as populations age and urbanize, and as obesity becomes more prevalent/5.

Metformin falls into a category of a biguanide molecule. Biguanides are derivatives of guanidine, a naturally occurring substance found in vegetables such as turnips and cereals. They exert a blood glucose-lowering effect in type 2 (non-insulin dependent) diabetes mellitus, and since they do not increase plasma insulin concentrations and do not.

Even at that time, diabetes was seen as a disease of urban life. There are two main types of diabetes. Type 1 diabetes, also known as insulin-dependent diabetes mellitus, is an autoimmune disorder associated with MHC genes (Campbell and Milner ). Type 2 diabetes, known as non-insulin-dependent diabetes mellitus, is a complex multifactorial /5.

Type 11 diabetes known as non-insulin-dependent diabetes mellitus (NIDDM) because patients with this type may or may not rely on the use of exogenous insulin for survival. Diet, obesity, allergies to certain foods, viral infections, and stress are all factors that can contribute to.

Testosterone deficiency, diabetes and the metabolic syndrome. The association between low levels of testosterone (a condition known as hypogonadism) and type 2 diabetes mellitus are well recognised, but it also appears that testosterone deficiency is common in men with diabetes regardless of type.

Metabolic syndrome is a condition characterised by several co-occurring metabolic imbalances (e.g. The widespread recognition that aging is a major risk factor for the development of diabetes has led some to believe that glucose intolerance is an inevitable outcome of aging.

Mandelbaum D, Reaven GM: Dietary management of nursing home residents with non-insulin dependent diabetes mellitus. Am J Clin Nutr  Diabetes Mellitus is characterised by an elevation of blood glucose caused by a relative or absolute deficiency of insulin.

Diabetes Mellitus can be divided into two main groups Insulin dependent Diabetes Mellitus (Type 1) and Non insulin dependent Diabetes Mellitus (Type 2). Hyperinsulinemia in a normal population as a predictor of non—insulin-dependent diabetes mellitus, hypertension, and coronary heart disease: The Barilla factory revisited.] 2.

is the blood glucose normal range too high, perhaps because it was established from a group of possibly (or probably) abnormal individuals; as was probably true for.Harris MI, Hadden WC, Knowler WC, Bennett PH.

Prevalence of diabetes and impaired glucose tolerance and plasma glu- cose levels in US population aged yr. Diabetes. Apr;36(4) Mayfield J. Diagnosis and classification of diabetes mellitus: new criteria. Am Fam Physician.

Oct;58(6) Animal models of obesity are highly associated with observations of reduced glucose tolerance (61), and in the non-human primate this glucose intolerance precedes overt type 2 diabetes, as recently Longitudinal in vivo studies in rhesus monkeys have shown that as obese monkeys begin to make the final transition from impaired insulin sensitivity /5.